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1

Antibiotic resistance of bacterial biofilms

Niels Høiby, Thomas Bjarnsholt, Michael Givskov, Søren Molin, Oana Ciofu

Journal:

International Journal of Antimicrobial Agents

Year:

2010

Language:

english

File:

PDF, 2.57 MB

english, 2010

2

Reinforcement of the bactericidal effect of ciprofloxacin on Pseudomonas aeruginosa biofilm by hyperbaric oxygen treatment

Kolpen, Mette, Mousavi, Nabi, Sams, Thomas, Bjarnsholt, Thomas, Ciofu, Oana, Moser, Claus, Kühl, Michael, Høiby, Niels, Jensen, Peter Østrup

Journal:

International Journal of Antimicrobial Agents

Year:

2015

Language:

english

File:

PDF, 876 KB

english, 2015

3

Evolution of antibiotic resistance in biofilm and planktonic P. aeruginosa populations exposed to sub-inhibitory levels of ciprofloxacin

Ahmed, Marwa N., Porse, Andreas, Sommer, Morten Otto Alexander, Høiby, Niels, Ciofu, Oana

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2018

Language:

english

File:

PDF, 1.35 MB

english, 2018

4

The clinical impact of bacterial biofilms

Høiby, Niels, Ciofu, Oana, Johansen, Helle Krogh, Song, Zhi‐jun, Moser, Claus, Jensen, Peter Østrup, Molin, Søren, Givskov, Michael, Tolker‐Nielsen, Tim, Bjarnsholt, Thomas

Journal:

International Journal of Oral Science

Year:

2011

Language:

english

File:

PDF, 704 KB

english, 2011

5

Hyperbaric oxygen sensitizes anoxic Pseudomonas aeruginosa biofilm to ciprofloxacin

Kolpen, Mette, Lerche, Christian J., Kragh, Kasper N., Sams, Thomas, Koren, Klaus, Jensen, Anna S., Line, Laura, Bjarnsholt, Thomas, Ciofu, Oana, Moser, Claus, Kühl, Michael, Høiby, Niels, Jensen, Pet

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2017

Language:

english

File:

PDF, 756 KB

english, 2017

6

Phenotypes selected during chronic lung infection in cystic fibrosis patients: implications for the treatment of Pseudomonas aeruginosa biofilm infections

Oana Ciofu, Lotte F. Mandsberg, Hengzhuang Wang, Niels Høiby

Journal:

FEMS Immunology & Medical Microbiology

Year:

2012

Language:

english

File:

PDF, 1.11 MB

english, 2012

7

Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective

Folkesson, Anders, Jelsbak, Lars, Yang, Lei, Johansen, Helle Krogh, Ciofu, Oana, Høiby, Niels, Molin, Søren

Journal:

Nature Reviews Microbiology

Year:

2012

Language:

english

File:

PDF, 744 KB

english, 2012

8

Respiratory bacterial infections in cystic fibrosis

Ciofu, Oana, Hansen, Christine R., Høiby, Niels

Journal:

Current Opinion in Pulmonary Medicine

Year:

2013

Language:

english

File:

PDF, 231 KB

english, 2013

9

Antibiotic treatment of biofilm infections

Ciofu, Oana, Rojo-Molinero, Estrella, Macià, María D., Oliver, Antonio

Journal:

Year:

2017

Language:

english

File:

PDF, 259 KB

english, 2017

10

Antioxidant supplementation for lung disease in cystic fibrosis

Ciofu, Oana, Smith, Sherie, Lykkesfeldt, Jens

Journal:

Cochrane database of systematic reviews

Year:

2019

Language:

english

File:

PDF, 1.43 MB

english, 2019

11

Pseudomonas aeruginosa biofilms in cystic fibrosis

Høiby, Niels, Ciofu, Oana, Bjarnsholt, Thomas

Journal:

Future Microbiology

Year:

2010

Language:

english

File:

PDF, 2.63 MB

english, 2010

12

The effect of short-term, high-dose oral N-acetylcysteine treatment on oxidative stress markers in cystic fibrosis patients with chronic P. aeruginosa infection — A pilot study

Skov, Marianne, Pressler, Tacjana, Lykkesfeldt, Jens, Poulsen, Henrik Enghusen, Jensen, Peter Østrup, Johansen, Helle Krogh, Qvist, Tavs, Kræmer, Dorthe, Høiby, Niels, Ciofu, Oana

Journal:

Journal of Cystic Fibrosis

Year:

2015

Language:

english

File:

PDF, 391 KB

english, 2015

13

Effect of Long-Term Voluntary Exercise Wheel Running on Susceptibility to Bacterial Pulmonary Infections in a Mouse Model

van de Weert – van Leeuwen, Pauline B., de Vrankrijker, Angélica M. M., Fentz, Joachim, Ciofu, Oana, Wojtaszewski, Jørgen F. P., Arets, Hubertus G. M., Hulzebos, Hendrikus J., van der Ent, Cornelis K.

Journal:

Year:

2013

Language:

english

File:

PDF, 501 KB

english, 2013

14

Development of antibiotic resistance and up-regulation of the antimutator gene pfpI in mutator Pseudomonas aeruginosa due to inactivation of two DNA oxidative repair genes (mutY, mutM)

Lotte Frigaard Mandsberg, Maria D. Maciá, Kirsten R. Bergmann, Lasse E. Christiansen, Morten Alhede, Nikolai Kirkby, Niels Høiby, Antonio Oliver, Oana Ciofu

Journal:

FEMS Microbiology Letters

Year:

2011

Language:

english

File:

PDF, 178 KB

english, 2011

15

Antibodies against Pseudomonas aeruginosa chromosomal β-lactamase in patients with cystic fibrosis are markers of the development of resistance of P. aeruginosa to β-lactams

Ciofu, Oana, Giwercman, Birgit, Walter-Rasmussen, Jan, Pressler, Tacjana, Pedersen, Svend Stenvang, Høiby, Niels

Journal:

Journal of Antimicrobial Chemotherapy

Year:

1995

Language:

english

File:

PDF, 1.80 MB

english, 1995

16

Physiological levels of nitrate support anoxic growth by denitrification of Pseudomonas aeruginosa at growth rates reported in cystic fibrosis lungs and sputum

Line, Laura, Alhede, Morten, Kolpen, Mette, KÃ¼hl, Michael, Ciofu, Oana, Bjarnsholt, Thomas, Moser, Claus, Toyofuku, Masanori, Nomura, Nobuhiko, HÃ¸iby, Niels, Jensen, Peter Ã˜.

Journal:

Frontiers in Microbiology

Year:

2014

Language:

english

File:

PDF, 1.15 MB

english, 2014

17

Genome Sequence of Pseudomonas aeruginosa Strain DK1-NH57388A, a Stable Mucoid Cystic Fibrosis Isolate

Norman, Anders, Ciofu, Oana, Amador, Cristina Isabel, Høiby, Niels, Jelsbak, Lars

Journal:

Genome Announcements

Year:

2016

Language:

english

File:

PDF, 144 KB

english, 2016

18

Detection of multidrug-resistant bacteria in the occupied Palestinian territory: a cross-sectional study

Sjölander, Isabella, Hansen, Frank, Elmanama, Abdelraouf, Khayyat, Rasha, Abu-Zant, Alaeddin, Hussein, Ayman, Taha, Adham Abu, Hammerum, Anette M, Ciofu, Oana

Journal:

Lancet (London, England)

Year:

2017

Language:

english

File:

PDF, 64 KB

english, 2017

19

Cellular responses of A549 alveolar epithelial cells to serially collected Pseudomonas aeruginosa from cystic fibrosis patients at different stages of pulmonary infection

Nicole A. Hawdon, Pouya Sadeghi Aval, Rebecca J. Barnes, Sean K. Gravelle, Jessica Rosengren, Sarah Khan, Oana Ciofu, Helle Krogh Johansen, Niels Høiby, Marina Ulanova

Journal:

FEMS Immunology & Medical Microbiology

Year:

2010

Language:

english

File:

PDF, 277 KB

english, 2010

20

Within-host microevolution of Pseudomonas aeruginosa in Italian cystic fibrosis patients

Marvig, Rasmus Lykke, Dolce, Daniela, Sommer, Lea M., Petersen, Bent, Ciofu, Oana, Campana, Silvia, Molin, Søren, Taccetti, Giovanni, Johansen, Helle Krogh

Journal:

BMC Microbiology

Year:

2015

Language:

english

File:

PDF, 734 KB

english, 2015

21

P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs

Ciofu, Oana, Johansen, Helle Krogh, Aanaes, Kasper, Wassermann, Tina, Alhede, Morten, von Buchwald, Christian, Høiby, Niels

Journal:

Journal of Cystic Fibrosis

Year:

2013

Language:

english

File:

PDF, 499 KB

english, 2013

22

OligoG CF-5/20 disruption of mucoid Pseudomonas aeruginosa biofilm in a murine lung infection model

Hengzhuang, Wang, Song, Zhijun, Ciofu, Oana, Onsøyen, Edvar, Rye, Philip D., Høiby, Niels

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2016

Language:

english

File:

PDF, 5.65 MB

english, 2016

23

Proteome-wide antigen discovery of novel protective vaccine candidates against Staphylococcus aureus infection

Rasmussen, Karina Juhl, Mattsson, Andreas Holm, Pilely, Katrine, Asferg, Cecilie Antoinette, Ciofu, Oana, Vitved, Lars, Koch, Claus, Kemp, Michael

Journal:

Year:

2016

Language:

english

File:

PDF, 394 KB

english, 2016

24

Diet and Exercise in Cystic Fibrosis || Chronic Infection with Pseudomonas aeruginosa in an Animal Model of Oxidative Stress

Year:

2015

Language:

english

File:

PDF, 339 KB

english, 2015

25

Applying insights from biofilm biology to drug development — can a new approach be developed?

Bjarnsholt, Thomas, Ciofu, Oana, Molin, Søren, Givskov, Michael, Høiby, Niels

Journal:

Nature Reviews Drug Discovery

Year:

2013

Language:

english

File:

PDF, 1.52 MB

english, 2013

26

Mucoid Pseudomonas aeruginosa isolates maintain the biofilm formation capacity and the gene expression profiles during the chronic lung infection of CF patients

BAOLERI LEE, CHARLOTTE K. SCHJERLING, NIKOLAI KIRKBY, NADINE HOFFMANN, REHANNAH BORUP, SØREN MOLIN, NIELS HØIBY, OANA CIOFU

Journal:

Year:

2011

Language:

english

File:

PDF, 2.17 MB

english, 2011

27

Detection of NDM-2-producing Acinetobacter baumannii and VIM-producing Pseudomonas aeruginosa in Palestine

Sjölander, Isabella, Hansen, Frank, Elmanama, Abdelraouf, Khayyat, Rasha, Abu-Zant, Alaeddin, Hussein, Ayman, Taha, Adham Abu, Hammerum, Anette M., Ciofu, Oana

Journal:

Journal of Global Antimicrobial Resistance

Year:

2014

Language:

english

File:

PDF, 228 KB

english, 2014

28

Phenotypic shift in Pseudomonas aeruginosa populations from cystic fibrosis lungs after 2-week antipseudomonal treatment

Fernández-Barat, Laia, Ciofu, Oana, Kragh, Kasper N., Pressler, Tania, Johansen, Ulla, Motos, Anna, Torres, Antoni, Hoiby, Niels

Journal:

Journal of Cystic Fibrosis

Year:

2016

Language:

english

File:

PDF, 1.07 MB

english, 2016

29

Molecular Epidemiology of Chronic Pseudomonas aeruginosa Airway Infections in Cystic Fibrosis

Cramer, Nina, Wiehlmann, Lutz, Ciofu, Oana, Tamm, Stephanie, Høiby, Niels, Tümmler, Burkhard, Gulbins, Erich

Journal:

Year:

2012

Language:

english

File:

PDF, 710 KB

english, 2012

30

Antibiotic therapy as personalized medicine – general considerations and complicating factors

Moser, Claus, Lerche, Christian Johann, Thomsen, Kim, Hartvig, Tom, Schierbeck, Jens, Jensen, Peter Østrup, Ciofu, Oana, Høiby, Niels

Journal:

Year:

2019

File:

PDF, 888 KB

2019

31

Bactericidal effect of colistin on planktonic Pseudomonas aeruginosa is independent of hydroxyl radical formation

Brochmann, Rikke Prejh, Toft, Anders, Ciofu, Oana, Briales, Alejandra, Kolpen, Mette, Hempel, Casper, Bjarnsholt, Thomas, Høiby, Niels, Jensen, Peter Østrup

Journal:

International Journal of Antimicrobial Agents

Year:

2014

Language:

english

File:

PDF, 634 KB

english, 2014

32

IgG avidity to Pseudomonas aeruginosa over the course of chronic lung biofilm infection in cystic fibrosis

Mauch, Renan Marrichi, Nørregaard, Lena Lingren, Ciofu, Oana, Levy, Carlos Emilio, Høiby, Niels

Journal:

Journal of Cystic Fibrosis

Year:

2017

Language:

english

File:

PDF, 225 KB

english, 2017

33

Poor Antioxidant Status Exacerbates Oxidative Stress and Inflammatory Response to Pseudomonas aeruginosa Lung Infection in Guinea Pigs

Peter Ø. Jensen, Jens Lykkesfeldt, Thomas Bjarnsholt, Hans P. Hougen, Niels Høiby, Oana Ciofu

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2012

Language:

english

File:

PDF, 317 KB

english, 2012

34

Diversity of metabolic profiles of cystic fibrosis Pseudomonas aeruginosa during the early stages of lung infection

Ciofu, Oana, Molin, Søren, Wassermann, Tina, Johansen, Helle Krogh, Høiby, Niels, Jørgensen, Karin Meinike, Christiansen, Lasse Engbo

Journal:

Microbiology (Society for General Microbiology)

Year:

2015

Language:

english

File:

PDF, 2.11 MB

english, 2015

35

Rapid development in vitro and in vivo of resistance to ceftazidime in biofilm-growing Pseudomonas aeruginosa due to chromosomal β-lactamase

NIELS Bagge, OANA Ciofu, LENE T. Skovgaard, NIELS HØIby

Journal:

Year:

2000

Language:

english

File:

PDF, 1.00 MB

english, 2000

36

Spread of colistin resistant non-mucoid Pseudomonas aeruginosa among chronically infected Danish cystic fibrosis patients

Helle Krogh Johansen, Samuel M. Moskowitz, Oana Ciofu, Tacjana Pressler, Niels Høiby

Journal:

Journal of Cystic Fibrosis

Year:

2008

Language:

english

File:

PDF, 488 KB

english, 2008

37

Diagnosis of biofilm infections in cystic fibrosis patients

Høiby, Niels, Bjarnsholt, Thomas, Moser, Claus, Jensen, Peter Østrup, Kolpen, Mette, Qvist, Tavs, Aanaes, Kasper, Pressler, Tanja, Skov, Marianne, Ciofu, Oana

Journal:

Year:

2017

Language:

english

File:

PDF, 553 KB

english, 2017

38

Antibiotic therapy as personalized medicine – general considerations and complicating factors

Moser, Claus, Lerche, Christian Johann, Thomsen, Kim, Hartvig, Tom, Schierbeck, Jens, Jensen, Peter Østrup, Ciofu, Oana, Høiby, Niels

Journal:

Year:

2019

Language:

english

File:

PDF, 888 KB

english, 2019

39

Tolerance and Resistance of Pseudomonas aeruginosa Biofilms to Antimicrobial Agents—How P. aeruginosa Can Escape Antibiotics

Ciofu, Oana, Tolker-Nielsen, Tim

Journal:

Frontiers in Microbiology

Year:

2019

Language:

english

File:

PDF, 955 KB

english, 2019

40

Novel experimental Pseudomonas aeruginosa lung infection model mimicking long-term host–pathogen interactions in cystic fibrosis

CLAUS MOSER, MARIA VAN GENNIP, THOMAS BJARNSHOLT, PETER ØSTRUP JENSEN, BAOLERI LEE, HANS PETTER HOUGEN, HENRIK CALUM, OANA CIOFU, MICHAEL GIVSKOV, SØREN MOLIN, NIELS HØIBY

Journal:

Year:

2009

Language:

english

File:

PDF, 794 KB

english, 2009

41

Meropenem in cystic fibrosis patients infected with resistant Pseudomonas aeruginosa or Burkholderia cepacia and with hypersensitivity to β-lactam antibiotics

Oana Ciofu, Tim Jensen, Tacjana Pressler, Helle Krogh Johansen, Christian Koch, Niels Hoiby

Journal:

Clinical Microbiology and Infection

Year:

1996

Language:

english

File:

PDF, 577 KB

english, 1996

42

Formation of hydroxyl radicals contributes to the bactericidal activity of ciprofloxacin against Pseudomonas aeruginosa biofilms

Jensen, Peter Ø., Briales, Alejandra, Brochmann, Rikke P., Wang, Hengzhuang, Kragh, Kasper N., Kolpen, Mette, Hempel, Casper, Bjarnsholt, Thomas, Høiby, Niels, Ciofu, Oana

Journal:

Pathogens and Disease

Year:

2014

Language:

english

File:

PDF, 433 KB

english, 2014

43

Pseudomonas aeruginosa and the in vitroand in vivo biofilm mode of growth

Niels Høiby, Helle Krogh Johansen, Claus Moser, Zhijun Song, Oana Ciofu, Arsalan Kharazmi

Journal:

Microbes and Infection

Year:

2001

Language:

english

File:

PDF, 337 KB

english, 2001

44

Real-Time Monitoring of nfxB Mutant Occurrence and Dynamics in Pseudomonas aeruginosa Biofilm Exposed to Subinhibitory Concentrations of Ciprofloxacin

Zaborskyte, Greta, Andersen, Jens Bo, Kragh, Kasper Nørskov, Ciofu, Oana

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2017

Language:

english

File:

PDF, 2.44 MB

english, 2017

45

P. aeruginosa flow-cell biofilms are enhanced by repeated phage treatments but can be eradicated by phage-ciprofloxacin combination

Henriksen, Karoline, Rørbo, Nanna, Rybtke, Morten Levin, Martinet, Mark Grevsen, Tolker-Nielsen, Tim, Høiby, Niels, Middelboe, Mathias, Ciofu, Oana

Journal:

Pathogens and Disease

Year:

2019

Language:

english

File:

PDF, 1.18 MB

english, 2019

46

Phenotypes selected during chronic lung infection in cystic fibrosis patients: implications for the treatment of Pseudomonas aeruginosa biofilm infections

Oana Ciofu, Lotte F. Mandsberg, Hengzhuang Wang, Niels Høiby

Journal:

FEMS Immunology & Medical Microbiology

Year:

2012

Language:

english

File:

PDF, 642 KB

english, 2012

47

Respiratory syncytial virus infection facilitates acute colonization of Pseudomonas aeruginosa in mice

Angélica M.M. de Vrankrijker, Tom F.W. Wolfs, Oana Ciofu, Niels Høiby, Cornelis K. van der Ent, Steen S. Poulsen, Helle Krogh Johansen

Journal:

Journal of Medical Virology

Year:

2009

Language:

english

File:

PDF, 336 KB

english, 2009

48

A complex multilevel attack on Pseudomonas aeruginosa algT/U expression and AlgT/U activity results in the loss of alginate production

Robert Sautter, Damaris Ramos, Lisa Schneper, Oana Ciofu, Tina Wassermann, Chong-Lek Koh, Arne Heydorn, Morton Hentzer, Niels Høiby, Arsalan Kharazmi, Søren Molin, Caroline A. DeVries, Dennis E. Ohman

Journal:

Year:

2012

Language:

english

File:

PDF, 762 KB

english, 2012

49

Antimicrobial resistance, respiratory tract infections and role of biofilms in lung infections in cystic fibrosis patients

Ciofu, Oana, Tolker-Nielsen, Tim, Jensen, Peter Østrup, Wang, Hengzhuang, Høiby, Niels

Journal:

Advanced Drug Delivery Reviews

Year:

2015

Language:

english

File:

PDF, 1.98 MB

english, 2015

50

Increased bactericidal activity of colistin on Pseudomonas aeruginosa biofilms in anaerobic conditions

Kolpen, Mette, Appeldorff, Cecilie F., Brandt, Sarah, Mousavi, Nabi, Kragh, Kasper N., Aydogan, Sevtap, Uppal, Haleema A., Bjarnsholt, Thomas, Ciofu, Oana, Høiby, Niels, Jensen, Peter Ø.

Journal:

Pathogens and Disease

Year:

2015

Language:

english

File:

PDF, 474 KB

english, 2015

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